Spasticity related to amyotrophic lateral sclerosis.The treatment of acute and chronic akathisia induced by neuroleptics, also called antipsychotics.REM sleep behavior disorder responds well to low doses of clonazepam. Bruxism also responds to clonazepam in the short term. Restless legs syndrome can be treated using clonazepam as a third-line treatment option, as the use of clonazepam is still investigational. Clonazepam is also effective in the management of acute mania. Some long-term trials have suggested a benefit of clonazepam for up to three years without the development of tolerance, but these trials were not placebo-controlled. The effectiveness of clonazepam in the short-term treatment of panic disorder has been demonstrated in controlled clinical trials. Clonazepam has also been found effective in treating other anxiety disorders, such as social phobia, but this is an off-label use.Panic disorder may occur with or without agoraphobia.A subgroup of people with treatment resistant epilepsy may benefit from long-term use of clonazepam the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance. It is also approved for treatment of typical and atypical absences (seizures), infantile myoclonic, myoclonic, and akinetic seizures. Clonazepam has been found to be effective in the acute control of nonconvulsive status epilepticus the benefits, though, tended to be transient in many people, and the addition of phenytoin for lasting control was required in these patients. Clonazepam is mainly prescribed for the acute management of epilepsies. As a result, clonazepam is sometimes used for certain rare childhood epilepsies, but it has been found to be ineffective in the control of infantile spasms. Seizures Ĭlonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.Ĭlonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of clonazepam. Medical uses Ĭlonazepam is prescribed for short-term management of epilepsy, anxiety, OCD and panic disorder with or without agoraphobia. In many areas of the world, it is commonly used as a recreational drug. In 2020, it was the 44th-most commonly prescribed medication in the United States, with more than 14 million prescriptions. Ĭlonazepam was patented in 1960 and went on sale in 1975 in the United States from Roche. Clonazepam binds to GABA A receptors, thus increasing the effect of the chief inhibitory neurotransmitter γ-aminobutyric acid (GABA). Use during pregnancy may result in harm to the fetus. The risk of suicide increases, particularly in people who are already depressed. Dependence occurs in one-third of people who take benzodiazepines for longer than four weeks. Long-term use may result in tolerance, dependence, and withdrawal symptoms if stopped abruptly. Ĭommon side effects include sleepiness, poor coordination, and agitation. Effects begin within one hour and last between six and twelve hours. It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. It is a tranquilizer of the benzodiazepine class. Clonazepam, sold under the brand names Klonopin and Rivotril, is a medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, OCD and akathisia.
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